RNA Details
Disease Name
pulmonary fibrosis
Tissue
lung
RNA Symbol
mir-449a
RNA ID
RNA Type
miRNA
Alteration Pattern
down regulation
Species
mus musculus
Detection Methods
Immunofluorescence; qRT-PCR etc.
Target
Bcl2
Pathway
NA
PubMed ID
Title
MiR-449a regulates autophagy to inhibit silica-induced pulmonary fibrosis through targeting Bcl2
Year
2016
Function
MiR-449a expression was decreased in fibrotic lungs and activated fibroblasts. Autophagy was inhibited in fibrotic lung tissues and TGF-B1-treated fibroblasts. MiR-449a had an antifibrotic effect in silica-induced lung fibrosis. MiR-449a upregulated autophagic activity in vitro. Bcl2 is the autophagy-related target of miR-449a. TGF-B1 increase the expression of Bcl2 via the MAPK/ERK pathway.